Caring for children diagnosed with life-threatening or end-of-life conditions requires a special, holistic approach within an interdisciplinary team. Love, empathy, patience, kindness, gentleness are virtues that must characterize the people involved in pediatric palliative care. Interviews with medical staff, accompanying parents and minor patients with life-threatening diseases, based on open-ended questions, revealed their authentic feelings, concerns, fears, anxieties and faith. The research methods used are documentation and semi-directive interview, and the study was carried out between September 2020 and February 2023, at the “Sfânta Maria” Childrens Hospital in Iasi, which serves pediatric patients in the North-East region of Romania, one of the largest hospitals in Romania. The purpose of the research is to capture relevant hypostases of moral responsibility and religious assistance within pediatric palliative care. The objectives of the research were to identify the perceptions regarding illness and suffering and to capture the usefulness of religious assistance and spiritual guidance.